Key result
Three frailty domains linked to ~104% higher risk of 1-year HF readmission or death.
Why the study?
The prevalence, overlap, and prognostic implications of physical frailty, social frailty, and cognitive dysfunction in hospitalized elderly patients with heart failure were unclear.
Does the coexistence of multiple frailty domains increase the risk of heart failure rehospitalization and all-cause death in hospitalized elderly patients with heart failure?
Population
1180 hospitalized heart failure patients aged ≥65 years
Comparison
1, 2, or 3 frailty domains vs 0 domains
Design
Prospective multicentre cohort study
Follow-up
1 year
Authors
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Multiple frailty domains may aid risk stratification in elderly HF inpatients; leaves open whether targeted interventions improve outcomes.
Cohort (n=1,180)
Yes
Does the coexistence of multiple frailty domains increase the risk of heart failure rehospitalization and all-cause death in hospitalized elderly patients with heart failure?
Effect estimate: HR 2.04 (95% CI 1.28-3.24)
p-value: p=0.003
The coexistence of multiple frailty domains is highly prevalent in elderly hospitalized heart failure patients and provides additive prognostic value for predicting 1-year mortality and rehospitalization.
Matsue et al. (2020) conducted a cohort in heart failure (n=1,180). Multiple frailty domains vs. 0 frailty domains was evaluated on combined endpoint of heart failure rehospitalization and all-cause death within 1 year (HR 2.04, 95% CI 1.28-3.24, p=0.003). Having 3 frailty domains versus 0 domains significantly increased the risk of 1-year heart failure rehospitalization or all-cause death (HR 2.04; 95% CI 1.28-3.24; P=0.003).
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