Key result
Higher atherogenic LDL scores in hypertensive patients correlated significantly with the 10-year Framingham coronary heart disease risk score and negatively with flow-mediated dilation (both P<0.001).
Why the study?
Does cardiovascular risk factor management improve atherogenic lipoprotein profiles and endothelial dysfunction in high-risk hypertensive patients?
Population
84 high-risk hypertensive patients and 61 age- and gender-matched healthy normotensive control subjects.
Comparison
6 months of cardiovascular risk factor management vs Baseline levels compared with 61 age- and…
Design
Cohort
Follow-up
6 months
Authors
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May indicate atherogenic LDL role in hypertensive vascular risk; leaves open whether management improves profiles and endothelial function.
Observational (n=145)
Does cardiovascular risk factor management improve atherogenic lipoprotein profiles and endothelial dysfunction in high-risk hypertensive patients?
p-value: p=<0.001
Felmeden et al. (2003) conducted an observational in Hypertension (n=145). Cardiovascular risk factor management vs. Healthy normotensive control subjects was evaluated on LDL score and flow-mediated dilation (FMD) (p=<0.001). Higher atherogenic LDL scores in hypertensive patients correlated significantly with the 10-year Framingham coronary heart disease risk score and negatively with flow-mediated dilation (both P<0.001).
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