Key result
During sustained atrial fibrillation, cycle lengths were longer in arrhythmogenic (130 ms) and nonarrhythmogenic pulmonary veins (152 ms) than in the left atrial posterior wall (116 ms, P<0.001).
Why the study?
Does the electrical activity generated inside the pulmonary veins contribute to the maintenance of atrial fibrillation?
Population
22 patients with persistent or intermittent atrial fibrillation not related to rheumatic heart disease.
Comparison
Simultaneous electrophysiological mapping of the… vs Arrhythmogenic PVs vs nonarrhythmogenic PVs, and…
Design
Cohort
Authors
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Pulmonary vein activity during sustained AF appears driven by the left atrial posterior wall; hypothesis-generating for ablation strategies beyond pulmonary vein isolation.
Observational (n=22)
Does the electrical activity generated inside the pulmonary veins contribute to the maintenance of atrial fibrillation?
Absolute Event Rate: 130% vs 152%
p-value: p=<0.001
During sustained atrial fibrillation, electrical activity in the pulmonary veins originates from the posterior wall of the left atrium rather than focal firing, indicating PVs do not maintain the arrhythmia.
Ndrepepa et al. (2003) conducted an observational in Atrial fibrillation (n=22). Electrophysiological mapping vs. Arrhythmogenic vs nonarrhythmogenic pulmonary veins was evaluated on AF cycle lengths in arrhythmogenic vs nonarrhythmogenic pulmonary veins (ms) (p=<0.001). During sustained atrial fibrillation, cycle lengths were longer in arrhythmogenic (130 ms) and nonarrhythmogenic pulmonary veins (152 ms) than in the left atrial posterior wall (116 ms, P<0.001).
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