Key result
Genetic variations of the tyrosine hydroxylase gene, particularly the C-824T polymorphism, are associated with sympathetic overactivity and the development of primary hypertension.
This review highlights the potential role of genetic variations in tyrosine hydroxylase in driving sympathetic overactivity and contributing to the pathogenesis of primary hypertension.
One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of TH could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Here, we discuss the role of TH as a regulator of sympathetic activity and review several studies that investigated the relationship between genetic variations of TH and hypertension.
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Lee et al. (2016) conducted a review in Hypertension. Tyrosine hydroxylase genetic variations was evaluated. Genetic variations of the tyrosine hydroxylase gene, particularly the C-824T polymorphism, are associated with sympathetic overactivity and the development of primary hypertension.
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