Key result
TH promoter polymorphism C-824T is linked to ~3% of population diastolic blood pressure variance.
Why the study?
Common genetic variation at the human tyrosine hydroxylase locus may alter autonomic activity and predispose to cardiovascular disease, but its contributions were unclear.
Comparison
TH promoter haplotype variants and C-824T genotype effects on sympathetic traits and blood pressure
Design
Case-control study with polymorphism discovery and functional assays
Authors
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TH C-824T may raise male DBP; leaves open causal role in hypertension.
Case-Control (n=1,266)
Effect estimate: 3.4% of variance explained
p-value: p=0.044
Rao et al. (2008) conducted a case-control in Hypertension (n=1,266). TH promoter polymorphism C-824T vs. Wild-type C allele was evaluated on Diastolic blood pressure variance (3.4% of variance explained, p=0.044). The TH promoter polymorphism C-824T accounted for 3.4% of population diastolic blood pressure variance, with the minor T allele significantly increasing blood pressure in males.
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