Key result
Tyrosine hydroxylase TCAT repeat polymorphism predicts autonomic traits with ~61% heritability for heart rate.
Why the study?
Does variation at the (TCAT)(n) repeat polymorphism in the tyrosine hydroxylase gene influence autonomic nervous system traits and response to stress in human twins?
Population
Human twins, including normotensive twins at genetic risk of hypertension
Comparison
Variation at the repeat polymorphism in the… vs Different (TCAT)(n) alleles and diploid genotypes
Design
Cohort
Authors
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Supports heritable TH effects on autonomic traits in twins; leaves open hypertension risk prediction in broader populations.
Observational
Does variation at the (TCAT)(n) repeat polymorphism in the tyrosine hydroxylase gene influence autonomic nervous system traits and response to stress in human twins?
p-value: p=<0.0001
Common allelic variation within the tyrosine hydroxylase locus exerts a heritable effect on autonomic control of the circulation, potentially influencing the later development of hypertension.
Zhang et al. (2004) conducted an observational in Twins. Tyrosine hydroxylase (TCAT)n repeat polymorphism was evaluated on Heritability of norepinephrine secretion and heart rate (p=<0.0001). The tyrosine hydroxylase (TCAT)n repeat polymorphism predicted autonomic traits, with heritability up to 56.8% for norepinephrine secretion (P<0.0001) and 61% for heart rate (P<0.001).
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