Key result
Intraarterial infusion of prazosin led to a significantly greater increase in forearm blood flow in patients with essential hypertension compared to normotensive subjects.
Why the study?
Does intraarterial infusion of prazosin alter forearm blood flow differently in patients with essential hypertension compared to normotensive subjects?
Observational (n=40)
Does intraarterial infusion of prazosin alter forearm blood flow differently in patients with essential hypertension compared to normotensive subjects?
Patients with essential hypertension exhibit an enhanced postjunctional alpha-adrenoreceptor-mediated vasoconstrictor component compared to normotensive individuals.
Suggests enhanced alpha-adrenergic vasoconstriction in essential hypertension; hypothesis-generating and should not yet change practice.
Forearm blood flow (FAF) has been determined using venous occlusion plethysmography in 24 patients with essential hypertension (EHT) and in 16 age-matched normotensive subjects (NT) under basal resting conditions, following nonspecific vasodilatation with sodium nitroprusside and after intraarterial infusion of the postjunctional alpha-blocking drug, prazosin. Under basal conditions, FAF was significantly higher in EHT than in NT. Infusion of sodium nitroprusside produced a similar absolute increase in FAF in both groups, whereas postjunctional alpha-blockade with prazosin led to a significantly greater increase in FAF in EHT than in NT. A positive correlation was found between plasma epinephrine concentration and prazosin-induced FAF in EHT but not in NT. These results suggest an enhanced postjunctional alpha-adrenoreceptor-mediated vasoconstrictor component in established EHT.
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Amann et al. (1981) conducted an observational in Essential hypertension (n=40). Intraarterial infusion of prazosin and sodium nitroprusside vs. Normotensive subjects was evaluated on Forearm blood flow (FAF). Intraarterial infusion of prazosin led to a significantly greater increase in forearm blood flow in patients with essential hypertension compared to normotensive subjects.
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