January 1, 1980Hypertension
Norepinephrine in urine and plasma following provocative maneuvers in normal and hypertensive subjects.
Key result
Volume expansion and contraction altered urinary and plasma norepinephrine in 373 subjects, with hypertensive women exhibiting greater norepinephrine values than normal women or hypertensive men.
Why the study?
Does the response of urinary and plasma norepinephrine to volume expansion and contraction differ between normotensive and essential hypertensive subjects?
Population
373 men and women, comprising 266 normotensive subjects and 107 subjects with essential hypertension.
Comparison
Provocative maneuvers consisting of volume… vs Normotensive subjects compared to essential…
Design
Cross-sectional
Authors
Discussion
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Implication
Hypertensive women may exhibit sympathetic dysregulation; cross-sectional data leaves open causal role and need for prospective validation before clinical consideration.
Study Design
Type
Observational (n=373)
Structured PICO
Does the response of urinary and plasma norepinephrine to volume expansion and contraction differ between normotensive and essential hypertensive subjects?
P
Population
373 men and women, comprising 266 normotensive subjects and 107 subjects with essential hypertension.
I
Intervention
Provocative maneuvers consisting of volume expansion (2 liters of intravenous normal saline over 4 hours) and volume contraction (10 mEq sodium diet and 120 mg oral furosemide).
C
Comparator
Normotensive subjects compared to essential hypertensive subjects undergoing the same provocative maneuvers.
O
Outcome
Urinary norepinephrine (UNE) excretion rate and venous plasma norepinephrine (PNE) concentrations.surrogate
Hypertensive women exhibit altered sympathetic activity, characterized by elevated norepinephrine levels and a loss of normal physiological correlations between norepinephrine, blood pressure, and volume status.
Limitations
- Insufficient numbers of older subjects were available to exclude absolutely an age relationship among normals.
- Insufficient numbers of older subjects were available to exclude absolutely a relationship between PNE concentration and age among normals.
Cite This Study
Henry et al. (1980) conducted an observational in Essential hypertension (n=373). Volume expansion and volume contraction maneuvers vs. Normotensive subjects was evaluated on Urinary norepinephrine (UNE) excretion rate and venous plasma norepinephrine (PNE) concentrations. Volume expansion and contraction altered urinary and plasma norepinephrine in 373 subjects, with hypertensive women exhibiting greater norepinephrine values than normal women or hypertensive men.