Why the study?
How do plasma renin and aldosterone respond to volume expansion and contraction in normal subjects compared to patients with essential and secondary hypertension?
How do plasma renin and aldosterone respond to volume expansion and contraction in normal subjects compared to patients with essential and secondary hypertension?
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Volume expansion with saline infusion is a useful clinical maneuver to identify high-renin hypertension and primary aldosteronism, while age and race adjustments refine the categorization of low-renin hypertension.
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Grim et al. (1979) studied this question.
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