Why the study?
Does the response of renin release to stimuli differ between normotensive subjects and patients with different stages of essential hypertension?
Does the response of renin release to stimuli differ between normotensive subjects and patients with different stages of essential hypertension?
Patients with stage II essential hypertension exhibit suppressed renin release in response to stimuli, suggesting a relationship between renin suppression and hypertension progression.
Answers are grounded in this paper and cite their sources.
Blunted renin responsiveness marks stage II hypertension; hypothesis-generating for progression but requires prospective studies before any clinical use.
The responses of renin release to three different stimuli, such as 1) head-up tilt, 2) administration of loop diuretics(bumetanide) and 3) low sodium diet + administration of bumetanide + ambulation were examined in essential hypertensive patients and normotensive subjects. Essential hypertensive patients were classified as stage I and II according to WHO stage classification. Groups studied were age-matched. The responses of renin release to three stimuli did not significantly differ in normotensive subjects (n = 13, 42 +/- 2(SEM) years old) and essential hypertensive patients of stage I (n = 15, 44 +/- 2). However, essential hypertensive patients of stage II (n = 20, 44 +/- 1) showed significantly lower responses of renin release to all three stimuli than essential hypertensive patients of stage I and normotensive subjects. The results suggest that the suppression of renin release is related in part to the development of hypertension.
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Kokubu et al. (1980) studied this question.
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