Why the study?
Does acute volume depletion reveal abnormal responsiveness of the renin aldosterone system in patients with essential hypertension compared to normotensive volunteers?
Population
16 patients with essential hypertension and 12 normotensive volunteers (total n=28)
Comparison
Acute stimulation via acute volume depletion and… vs Normotensive volunteers receiving identical…
Design
Case-control
Authors
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May indicate adrenal-angiotensin defect in essential hypertension; hypothesis-generating without practice implications.
Does acute volume depletion reveal abnormal responsiveness of the renin aldosterone system in patients with essential hypertension compared to normotensive volunteers?
Patients with essential hypertension may have a defect in the interaction of angiotensin-II with the adrenal cortex, leading to blunted aldosterone secretion in response to acute volume depletion despite intact biosynthetic capacity.
Gordon H. Williams (1970) studied this question.
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