Key result
Essential hypertension is linked to a ~2-fold greater decrease in sodium excretion during angiotensin II infusion.
Why the study?
Is the antinatriuretic response to angiotensin II enhanced in men with essential hypertension compared to normotensive controls?
Population
120 white men, comprising 48 with essential hypertension and 72 normotensive controls.
Comparison
Angiotensin II infusion (0.5 and 3.0 ng/kg/min) vs Normotensive control group receiving the same…
Design
Case-control
Authors
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May indicate heightened sodium retention in essential hypertension; hypothesis-generating and should not yet change practice.
Case-Control (n=120)
Is the antinatriuretic response to angiotensin II enhanced in men with essential hypertension compared to normotensive controls?
Absolute Event Rate: -0.18% vs -0.09%
p-value: p=<.05
Patients with essential hypertension exhibit hyperresponsiveness to angiotensin II, leading to increased sodium retention independent of GFR and aldosterone changes.
Klingbeil et al. (2000) conducted a case-control in Essential hypertension (n=120). Essential hypertension vs. Normotensive controls was evaluated on Decrease in sodium excretion in response to 3.0 ng/kg/min angiotensin II (p=<.05). Essential hypertension was associated with a more pronounced decrease in sodium excretion in response to angiotensin II infusion compared to normotensive controls (-0.18 vs -0.09 mmol/min, P<0.05).
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