What question did this study set out to answer?

To determine whether sodium sensitivity is linked to altered renal hemodynamics and vascular responsiveness to angiotensin II in healthy normotensive individuals.

January 24, 2008American Journal of HypertensionOpen Access

Renal Response to Angiotensin II is Blunted in Sodium-sensitive Normotensive Men

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Why the study?

Does sodium sensitivity alter the renal hemodynamic response to angiotensin II in young healthy normotensive men?

Population

34 young healthy normotensive men

Comparison

Graded infusion of Angiotensin II evaluated… vs Sodium-resistant (SR) subjects

Design

Cohort

Follow-up

3 weeks (1 week per diet condition)

Authors

FVF. W. VisserUniversity Medical Center Groningen ABArnold H. BoonstraUniversity Medical Center Groningen ALA. Titia LelyUtrecht University

Discussion

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Implication

Blunted renal AngII response in sodium-sensitive normotensives corrected by ACEi; hypothesis-generating for intrarenal RAAS mechanisms, needs prospective validation.

Key Points

To determine whether sodium sensitivity is linked to altered renal hemodynamics and vascular responsiveness to angiotensin II in healthy normotensive individuals.
Evaluated 34 healthy men during three sequential 1-week dietary protocols: low-sodium (50 mmol/day), high-sodium (200 mmol/day), and high-sodium with enalapril (20 mg/day).
Assessed mean arterial pressure and measured effective renal plasma flow via (131)I-Hippuran clearance in response to graded infusions of angiotensin II across all three phases.
Sodium sensitivity (defined as an increase in mean arterial pressure >3 mm Hg on high sodium) was identified in 13 participants, who displayed lower effective renal plasma flow during low-sodium intake and during high-sodium intake with enalapril.
The reduction in effective renal plasma flow induced by angiotensin II was significantly blunted in sodium-sensitive subjects on the low-sodium diet (-25 ± 6% vs. -29 ± 7% in sodium-resistant subjects, P < 0.05) and on the high-sodium diet (-30 ± 5% vs. -35 ± 6%, P < 0.05).
Administration of enalapril reversed the vascular blunting in sodium-sensitive participants, bringing responses into alignment with sodium-resistant controls (-36 ± 6% vs. -37 ± 7%).

Structured PICO

Does sodium sensitivity alter the renal hemodynamic response to angiotensin II in young healthy normotensive men?

Population

34 young healthy normotensive men

Intervention

Graded infusion of Angiotensin II (AngII) evaluated under three conditions: 1-week low-sodium diet (50 mmol Na+/24 h), 1-week high-sodium diet (200 mmol Na+/24h), and 1-week high-sodium diet with enalapril 20 mg/day

Comparator

Sodium-resistant (SR) subjects

Outcome

Response of effective renal plasma flow (ERPF) to graded infusion of AngIIsurrogate

Sodium-sensitive normotensive men exhibit a blunted renal response to exogenous AngII that is corrected by ACE inhibition, suggesting that inappropriately high intrarenal RAAS activity may be a primary mechanism underlying sodium sensitivity.

Cite This Study

Visser et al. (2008) studied this question.

synapsesocial.com/papers/6a84065d356b31aeb3f2ef30 https://doi.org/10.1038/ajh.2007.63

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Implication

Blunted renal AngII response in sodium-sensitive normotensives corrected by ACEi; hypothesis-generating for intrarenal RAAS mechanisms, needs prospective validation.

Renal Response to Angiotensin II is Blunted in Sodium-sensitive Normotensive Men

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Renal Response to Angiotensin II is Blunted in Sodium-sensitive Normotensive Men

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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