Key result
In patients with coronary artery disease and depressed systolic function, left ventricular diastolic filling relies increasingly on slow filling as rapid filling is impaired (r=-0.73, p<0.001).
Why the study?
How do rapid filling, slow filling, and atrial systole contribute to left ventricular diastolic filling in patients with isolated LAD disease with normal versus depressed ejection fraction?
Observational (n=47)
How do rapid filling, slow filling, and atrial systole contribute to left ventricular diastolic filling in patients with isolated LAD disease with normal versus depressed ejection fraction?
Effect estimate: r = -0.73
p-value: p=<0.001
In patients with coronary artery disease and LV systolic dysfunction, the left ventricle relies increasingly on slow filling and atrial systole for diastolic filling as rapid filling is impaired.
No takes yet. Share an insight, caveat, or question.
Highlights compensatory slow filling in CAD with reduced EF; leaves open prospective validation before clinical application.
Yamagishi et al. (1990) conducted an observational in Coronary artery disease (n=47). Radionuclide ventriculography vs. Normal subjects was evaluated on Contributions of rapid filling, slow filling and atrial systole to the left ventricular filling volume (r = -0.73, p=<0.001). In patients with coronary artery disease and depressed systolic function, left ventricular diastolic filling relies increasingly on slow filling as rapid filling is impaired (r=-0.73, p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: