Key result
Bilinear regression better models the biphasic ESPVR during acute afterload increases in pigs.
Why the study?
The linearity and load insensitivity of the end-systolic pressure–volume relationship are controversial, hypothesized to be influenced by an overlay of shortening deactivation and the Frank-Starling mechanism.
Population
Twenty-four healthy pigs
Comparison
Preload reductions vs afterload increases vs preload reductions during increased afterload
Design
Animal experimental study
Authors
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Challenges linear ESPVR assumptions in models; leaves open translation from healthy pigs to clinical use.
Absolute Event Rate: 0.96% vs 0.929%
p-value: p=<0.05
The apparent non-linearity of the end-systolic pressure-volume relationship during acute afterload increases is caused by an overlay of shortening deactivation and the Frank-Starling mechanism, a finding that can improve cardiovascular simulation models.
Habigt et al. (2021) studied Healthy (cardiovascular physiology) (n=24). Afterload increases vs. Linear regression model was evaluated on Goodness of fit (r2) of ESPVR during afterload increases (p=<0.05). Acute afterload increases in healthy pigs caused a biphasic course of end-systolic pressure-volume points, resulting in a better fit for bilinear (r2 0.960) compared to linear (r2 0.929) regression.
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