Key result
End-systolic volume explains ~74% of the variance in end-systolic pressure in preclinical models.
Why the study?
The end-systolic pressure-volume relation strongly depends on the type of transient loading intervention in the in situ left ventricle, requiring additional variables to model and predict end-systolic pressure.
Population
16 open-chest anesthetized dogs in basal inotropic state
Comparison
Afterloading vs preloading transient loading interventions
Design
Reanalysis of 22 experiments using random-coefficients regression analysis
Authors
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Single-equation ESP prediction across loading types is feasible in canine LV; leaves open validation for human pressure-volume analysis.
In the in situ left ventricle, end-systolic pressure variance is primarily determined by end-systolic volume and stroke volume, allowing separation of force-length properties from shortening effects.
Linden et al. (1994) studied in situ left ventricle hemodynamics (n=16). transient loading interventions (afterloading and preloading) was evaluated on end-systolic pressure (ESP). In 16 anesthetized dogs, end-systolic volume and stroke volume accounted for 74% and 19% of the total variance in end-systolic pressure, respectively (overall R2=0.97).
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