What does this research mean for the field?

Left ventricular elastance (EES) can be accurately estimated from a single normally ejecting beat without altering preload or afterload, yielding results comparable to traditional variably loaded pressure-volume loops. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1993Cardiovascular Research

Estimation of left ventricular elastance without altering preload or afterload in the conscious dog

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Population

Conscious dogs instrumented to determine left ventricular volume from ultrasonic internal dimensions and…

Comparison

Estimation of left ventricular end systolic… vs EES determined from variably loaded left…

Design

Preclinical

Authors

TNTakaaki NakamotoDokkyo Medical University CCChristopher P. ChengMassachusetts General Hospital WSWilliam P. SantamoreRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Single-beat EES tracks contractility changes in conscious dogs; extends validation of noninvasive assessment but leaves clinical translation open.

Structured PICO

Population

Conscious dogs (n=10) instrumented to determine left ventricular volume from ultrasonic internal dimensions and left ventricular pressure using a micromanometer

Intervention

Estimation of left ventricular end systolic elastance (EES) from a single normally ejecting beat (EES-single beat) using Sunagawa's technique

Comparator

EES determined from variably loaded left ventricular pressure-volume (P-V) loops generated by vena caval occlusion

Outcome

Slope (EES) of the left ventricular end systolic pressure-volume linesurrogate

EES calculated from a single beat provides a reasonable method to estimate left ventricular contractility without altering preload or afterload in conscious dogs.

Cite This Study

Nakamoto et al. (1993) studied this question.

synapsesocial.com/papers/6a1d40dc28423f2ce504ebd5 https://doi.org/10.1093/cvr/27.5.868

Topics

Echocardiography

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Implication

Single-beat EES tracks contractility changes in conscious dogs; extends validation of noninvasive assessment but leaves clinical translation open.

Estimation of left ventricular elastance without altering preload or afterload in the conscious dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Estimation of left ventricular elastance without altering preload or afterload in the conscious dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

Also Consider