What does this research mean for the field?

The aortic occlusion method for assessing the slope (Emax) of the end-systolic pressure-volume line is a valid and useful measure of left ventricular contractility in the in situ dog heart. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1986AJP Heart and Circulatory Physiology

Assessment of slope of end-systolic pressure-volume line of in situ dog heart

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Population

Anesthetized open-chest dogs (n=9)

Comparison

Aortic occlusion method to assess the slope of… vs Control run

Design

Preclinical

Authors

YIY. IgarashiKanazawa University HSHiroyuki SugaShinshu University

Discussion

Member takes

Implication

Aortic occlusion tracks inotropic Emax changes in dogs; extends method validation but leaves human translation open.

Key Points

To establish and evaluate an aortic occlusion method for assessing the slope (Emax) of the end-systolic pressure-volume line to determine left ventricular contractility in the in situ heart.
Studied anesthetized open-chest dogs (N=9) by inducing isovolumic contractions via transient aortic occlusion following steady-state ejecting contractions in the left ventricle.
Plotted ventricular pressure from a catheter-tip manometer against time-integrated aortic flow from an electromagnetic flowmeter to derive the end-systolic pressure-volume relationship during baseline, isoproterenol, propranolol, and atrial pacing.
Left ventricular Emax increased by 59 ± 19% following isoproterenol administration and decreased by 47 ± 9% after propranolol administration in control dogs (n=9).
Variations in heart rate induced by atrial pacing produced little change in the measured slope (Emax).

Structured PICO

Population

Anesthetized open-chest dogs (n=9)

Intervention

Aortic occlusion method to assess the slope (Emax) of the end-systolic pressure-volume line (ESPVL), tested under conditions of isoproterenol, propranolol, and atrial pacing

Comparator

Control run

Outcome

Slope (Emax) of the end-systolic pressure-volume line (ESPVL)surrogate

The aortic occlusion method is a useful technique for assessing left ventricular contractility (Emax) in the in situ dog heart.

Cite This Study

Igarashi et al. (1986) studied this question.

synapsesocial.com/papers/6a1d40dc28423f2ce504ebda https://doi.org/10.1152/ajpheart.1986.250.4.h685

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Assessment of slope of end-systolic pressure-volume line of in situ dog heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Assessment of slope of end-systolic pressure-volume line of in situ dog heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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