Key result
Diabetes in aortic stenosis links to increased valve calcification in women and inflammation in men.
Why the study?
Diabetes mellitus accelerates aortic stenosis progression, but the interacting molecular mechanisms and potential contribution to sex-differences in aortic stenosis remain unclear.
Does diabetes mellitus produce sex-specific pathological phenotypes in the aortic valves of patients with severe aortic stenosis?
Population
283 patients with severe AS undergoing surgical valve replacement
Comparison
Patients with vs without concomitant DM, stratified by sex
Design
Observational cohort study with complementary in vitro experiments
Authors
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May inform sex-stratified phenotyping in diabetic AS; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=283)
No
Does diabetes mellitus produce sex-specific pathological phenotypes in the aortic valves of patients with severe aortic stenosis?
Diabetes mellitus drives sex-specific pathological changes in severe aortic stenosis, with women exhibiting a more pronounced pro-calcific phenotype that warrants consideration as a specific risk factor.
Martín‐Núñez et al. (2023) conducted an observational in Severe aortic stenosis (n=283). Diabetes Mellitus vs. Non-diabetic was evaluated on Pathological markers of aortic valve degeneration. Diabetes mellitus produces sex-specific pathological phenotypes in aortic valves of patients with aortic stenosis, with diabetic women showing increased calcification and men showing more inflammation.
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