Key result
Patients with severe aortic stenosis and concomitant type 2 diabetes had a 6.6-fold higher valvular expression of advanced glycation end products compared to non-diabetic patients.
Why the study?
Accumulation of advanced glycation end products (AGEs) leads to chronic glycation and tissue damage, particularly in diabetes, but whether increased AGE accumulation relates to aortic stenosis severity was unclear.
Comparison
Type 2 diabetes vs non-diabetes
Design
Prospective observational study
Authors
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DM-associated valvular AGE upregulation correlated with stenosis severity; leaves open whether AGE-RAGE targeting could modify diabetic valve disease progression.
Cross-Sectional (n=126)
No
Effect estimate: 6.6-fold higher
Absolute Event Rate: 15.53% vs 2.05%
p-value: p=<0.001
In patients with severe aortic stenosis, concomitant poorly-controlled type 2 diabetes is associated with increased valvular accumulation of advanced glycation end products (AGEs), which correlates with disease severity.
Kopytek et al. (2020) conducted a cross-sectional in Severe aortic stenosis (n=126). Type 2 diabetes mellitus vs. Non-diabetic patients with severe aortic stenosis was evaluated on Valvular expression of advanced glycation end products (AGEs) (6.6-fold higher, p=<0.001). Patients with severe aortic stenosis and concomitant type 2 diabetes had a 6.6-fold higher valvular expression of advanced glycation end products compared to non-diabetic patients.
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