Key result
Roux-en-Y gastric bypass improves weight, glucose, lipids, and adiponectin/leptin ratio at 6 months in obese women.
Why the study?
To investigate the adiponectin/leptin ratio and characterize blood biochemical, glucose, and inflammatory parameters before and after RYGB in women with severe obesity with and without MetS.
Does Roux-en-Y gastric bypass improve the adiponectin/leptin ratio and inflammatory profile in severely obese women with and without metabolic syndrome?
RCT (n=50)
Does Roux-en-Y gastric bypass improve the adiponectin/leptin ratio and inflammatory profile in severely obese women with and without metabolic syndrome?
Roux-en-Y gastric bypass significantly improves the adiponectin/leptin ratio and systemic inflammatory and biochemical parameters in severely obese women at 6 months, regardless of baseline metabolic syndrome status.
RYGB yields early metabolic and inflammatory benefits in severely obese women; extends evidence to adiponectin/leptin ratio independent of metabolic syndrome status.
Obesity is a troubling public health problem as it increases risks of sleep disorders, respiratory complications, systemic arterial hypertension, cardiovascular diseases, type 2 diabetes mellitus, and metabolic syndrome (MetS). As a measure to counteract comorbidities associated with severe obesity, bariatric surgery stands out. This study aimed to investigate the adiponectin/leptin ratio in women with severe obesity with and without MetS who had undergone Roux-en-Y gastric bypass (RYGB) and to characterize the biochemical, glucose, and inflammatory parameters of blood in women with severe obesity before and after RYGB. Were enrolled females with severe obesity undergoing RYGP with MetS (n = 11) and without (n = 39). Anthropometric data and circulating levels of glucose, total cholesterol, high-density lipoprotein (HDL), non-HDL total cholesterol, low-density lipoprotein (LDL), adiponectin, and leptin were assessed before and 6 months after RYGB. Significant reductions in weight, body mass index, and glucose, total cholesterol, LDL, and leptin were observed after surgery, with higher levels of HDL, adiponectin, and adiponectin/leptin ratio being observed after surgery compared to the preoperative values of those. This study demonstrated that weight loss induced by RYGB in patients with severe obesity with or without MetS improved biochemical and systemic inflammatory parameters, particularly the adiponectin/leptin ratio.
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Moreira et al. (2023) conducted an RCT in Severe obesity with and without metabolic syndrome (n=50). Roux-en-Y gastric bypass (RYGB) vs. Preoperative values was evaluated on Adiponectin/leptin ratio and biochemical, glucose, and inflammatory parameters. Roux-en-Y gastric bypass in severely obese women significantly improved weight, BMI, glucose, lipids, and the adiponectin/leptin ratio at 6 months compared to preoperative values.
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