Key result
Roux-en-Y gastric bypass improves weight, cardiometabolic profiles, and adiponectin/leptin ratio at 6 months in obese women.
Why the study?
Severe obesity markedly raises the risk of cardiovascular and metabolic comorbidities, but changes in the adiponectin/leptin ratio and blood inflammatory profile after Roux-en-Y gastric bypass in women with and without metabolic syndrome required investigation.
Does Roux-en-Y Gastric Bypass improve the adiponectin to leptin ratio and inflammatory profile in severely obese women with and without metabolic syndrome?
RCT (n=50)
Does Roux-en-Y Gastric Bypass improve the adiponectin to leptin ratio and inflammatory profile in severely obese women with and without metabolic syndrome?
Roux-en-Y Gastric Bypass significantly improves the adiponectin/leptin ratio, lipid profile, and glucose levels in severely obese women at 6 months, regardless of baseline metabolic syndrome status.
Supports RYGB for metabolic/inflammatory gains in obese women; extends RCT evidence to adiponectin/leptin ratio independent of metabolic syndrome.
Obesity is a troubling public health problem worldwide as it increases risks of respiratory complications, systemic arterial hypertension, type 2 diabetes mellitus, sleep disorders, cardiovascular diseases, and metabolic syndrome (MetS). As a measure to counteract comorbidities associated with severe obesity, bariatric surgery stands out. This study aimed to investigate the adiponectin/leptin ratio in women with severe obesity with and without MetS undergone Roux-en-Y Gastric Bypass (RYGB) and to characterize the biochemical, glucose, and inflammatory parameters of blood in women with severe obesity before and after RYGB. Were enrolled female with severe obesity undergoing RYGP with MetS (n=11) and without (n=39). Anthropometric data and blood samples were obtained before and 6 months after RYGB to analyze total cholesterol, low-density lipoprotein (LDL), high- density lipoprotein (HDL), non-HDL total cholesterol, and glucose; and circulating levels of adiponectin and leptin. Significant reductions in weight, body mass index, and glucose, total cholesterol, LDL, and leptin were observed after surgery, with higher levels of HDL, adiponectin, and adiponectin/leptin ratio observed after surgery compared to preoperative values. This study demonstrated that weight loss induced by RYGB in patients with severe obesity with or without MetS improved biochemical and systemic inflammatory parameters, particularly the adiponectin/leptin ratio.
No takes yet. Share an insight, caveat, or question.
Moreira et al. (2023) conducted an RCT in Severe obesity with and without metabolic syndrome (n=50). Roux-en-Y Gastric Bypass (RYGB) vs. Preoperative values was evaluated on Adiponectin/leptin ratio and biochemical, glucose, and inflammatory parameters. Roux-en-Y Gastric Bypass in severely obese women significantly improved weight, BMI, glucose, lipid profiles, and the adiponectin/leptin ratio at 6 months compared to preoperative values.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: