What does this research mean for the field?

Contraction-evoked substance P release in the spinal cord dorsal horn is proportional to developed muscle tension and plays a key role in mediating cardiovascular responses to static skeletal muscle contraction. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

December 1, 1993Circulation ResearchOpen Access

Effects of graded muscle contractions on spinal cord substance P release, arterial blood pressure, and heart rate.

View Full Paper

Ask AI

Bookmark

Population

alpha-chloralose-anesthetized cats

Comparison

High-tension muscle contractions vs Low-tension (LT) muscle contractions

Design

Preclinical

Follow-up

10 minutes

Authors

LWL. B. WilsonTulane University IFI FuchsThe University of Texas Southwestern Medical Center JMJ. H. MitchellTexas Health Harris Methodist Hospital Fort Worth

Discussion

Member takes

Implication

Augments animal evidence for substance P in the exercise pressor reflex; leaves open translation to human cardiovascular control.

Structured PICO

Population

alpha-chloralose-anesthetized cats

Intervention

High-tension (HT) muscle contractions (seven contractions over a 10-minute period, each 20 seconds in duration)

Comparator

Low-tension (LT) muscle contractions

Outcome

Release of substance P-like immunoreactivity (SP-LI) in the dorsal horn of the spinal cord, mean arterial pressure, and heart ratesurrogate

High-tension muscle contractions evoke greater substance P release in the spinal cord and larger cardiovascular responses than low-tension contractions, supporting the role of substance P in mediating cardiovascular responses to static skeletal muscle contraction.

Cite This Study

Wilson et al. (1993) studied this question.

synapsesocial.com/papers/6a1757bb3510de12de8d7cc5 https://doi.org/10.1161/01.res.73.6.1024

Topics

Thymosin beta-4

View Full Paper

Ask AI

Bookmark

Effects of graded muscle contractions on spinal cord substance P release, arterial blood pressure, and heart rate.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effects of graded muscle contractions on spinal cord substance P release, arterial blood pressure, and heart rate.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider