Why the study?
Does pretreatment with propranolol prevent subendocardial hypoperfusion and dysfunction during exercise in dogs with LV hypertrophy?
Does pretreatment with propranolol prevent subendocardial hypoperfusion and dysfunction during exercise in dogs with LV hypertrophy?
Beta-blockade with propranolol prevents exercise-induced subendocardial hypoperfusion and regional dysfunction in a canine model of LV hypertrophy.
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Hypothesis-generating in canine LV hypertrophy; leaves open human translation pending clinical trials.
Vatner et al. (1993) studied this question.
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