The Sequential Organ Failure Assessment (SOFA) score requires revision to incorporate modern clinical practices, such as updated respiratory support modalities and new cardiovascular drugs.
The sequential organ failure assessment (SOFA) score has been widely used for approximately 30 years for the clinical assessment and monitoring of organ dysfunction in patients. However, advancements in medical science and clinical practice have identified several limitations of the SOFA score, underscoring the need for its revision. This paper synthesizes and summarizes the recent advances and provides a comprehensive understanding of the deficiencies of the SOFA score, which requires certain refinements. Furthermore, this work presents a scientific basis and direction for further modifications to enhance the clinical utility of the score.
Yu et al. (2026) conducted a review in Organ dysfunction in critically ill patients. Sequential Organ Failure Assessment (SOFA) score update was evaluated. The Sequential Organ Failure Assessment (SOFA) score requires revision to incorporate modern clinical practices, such as updated respiratory support modalities and new cardiovascular drugs.