Key result
Right ventricular pressure overload induced differential activation of S6 kinase isoforms, with p70(S6K) activated >12-fold at 1 hour in the cytosol, followed by sustained p85(S6K) activation.
Population
Adult feline right ventricular pressure overload (RVPO) model
Design
Preclinical
Follow-up
up to 48 h
Authors
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Preclinical data on isoform-specific S6K activation in RV overload; leaves open human therapeutic relevance.
The study identifies a protein kinase C-mediated pathway that couples pressure overload to cardiac growth induction via differential spatial and temporal activation of S6 kinase isoforms.
Laser et al. (1998) studied Cardiac hypertrophy. Right ventricular pressure overload (RVPO) was evaluated on Activation of p70(S6K) and p85(S6K) isoforms. Right ventricular pressure overload induced differential activation of S6 kinase isoforms, with p70(S6K) activated >12-fold at 1 hour in the cytosol, followed by sustained p85(S6K) activation.
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