Key result
Myocardial infarction in rats eliminated regional differences in Ito density, APD, and [Ca2+]i transients between the right ventricular free wall and interventricular septum.
Absolute Event Rate: 8.7% vs 15%
p-value: p=<0.01
Myocardial infarction eliminates the normal regional differences in action potential duration, transient outward K+ currents, and calcium transients between the right ventricular free wall and interventricular septum in rats.
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MI homogenizes rat RV-septal electrophysiology post-infarct; hypothesis-generating for human remodeling and arrhythmia risk, requiring clinical validation.
Kaprielian et al. (2002) studied Myocardial infarction. Myocardial infarction vs. Sham operation was evaluated on Ito density in right ventricular free wall (RVW) myocytes at +40 mV (pA/pF) (p=<0.01). Myocardial infarction in rats eliminated regional differences in Ito density, APD, and [Ca2+]i transients between the right ventricular free wall and interventricular septum.
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