Key result
Lower Angiotensin I (A(1-10)) concentration was associated with ARDS survival (OR 0.36; 95% CI 0.18-0.72; p=0.004), while higher A(1-9) concentration also predicted survival.
Why the study?
Renin angiotensin system peptides may be critical in wound reparative processes, but their role in predicting clinical outcomes in ARDS had been unexplored.
Do circulating renin angiotensin system (RAS) peptide levels predict survival in patients with ARDS?
Observational (n=39)
Do circulating renin angiotensin system (RAS) peptide levels predict survival in patients with ARDS?
Plasma levels of angiotensin I (A(1-10)) and A(1-9) and their ratio may serve as prognostic biomarkers for survival in ARDS patients.
Answers are grounded in this paper and cite their sources.
May inform ARDS prognosis via RAS peptides; leaves open prospective validation before clinical use.
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Reddy et al. (2019) conducted an observational in Acute Respiratory Distress Syndrome (ARDS) (n=39). Plasma RAS peptide levels vs. Survivors vs non-survivors was evaluated on ARDS survival (association with A(1-10) concentration) (OR 0.36, 95% CI 0.18-0.72, p=0.004). Lower Angiotensin I (A(1-10)) concentration was associated with ARDS survival (OR 0.36; 95% CI 0.18-0.72; p=0.004), while higher A(1-9) concentration also predicted survival.
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