Key result
Acute respiratory distress syndrome was associated with increased angiotensin-converting enzyme activity and decreased angiotensin-converting enzyme 2 activity (p < 0.001) compared with controls.
Why the study?
Are pulmonary ACE and ACE2 activities altered in pediatric patients with acute respiratory distress syndrome?
Population
14 pediatric patients admitted to a PICU requiring mechanical ventilation for respiratory syncytial virus…
Design
Cohort
Authors
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Pediatric ARDS-linked ACE/ACE2 imbalance should not change practice; leaves open whether restoring angiotensin-(1-7) improves outcomes.
Observational (n=14)
No
Are pulmonary ACE and ACE2 activities altered in pediatric patients with acute respiratory distress syndrome?
p-value: p=< 0.001
In pediatric patients with ARDS, there is an imbalance between pulmonary ACE and ACE2 activity, suggesting a potential therapeutic role for restoring angiotensin-(1-7) levels.
Asperen et al. (2013) conducted an observational in Acute respiratory distress syndrome (n=14). Acute respiratory distress syndrome vs. Non-acute respiratory distress syndrome was evaluated on Angiotensin-converting enzyme and angiotensin-converting enzyme 2 activity in bronchoalveolar lavage fluid (p=< 0.001). Acute respiratory distress syndrome was associated with increased angiotensin-converting enzyme activity and decreased angiotensin-converting enzyme 2 activity (p < 0.001) compared with controls.
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