Key result
Severe pulmonary injury leaves lung angiotensin I conversion unimpeded, maintaining ~50% higher arterial angiotensin II.
Population
19 patients, the majority critically ill.
Design
Cross-sectional
Authors
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Intact pulmonary angiotensin conversion in severe injury does not support altering RAAS therapy; cross-sectional data leaves open its clinical relevance.
Observational (n=19)
The process of angiotensin I conversion in the lung operates without impediment despite severe pulmonary injury.
Wiberg-Jørgensen et al. (1983) conducted an observational in Respiratory failure (n=19). Severe pulmonary injury vs. Control patients above 50 years of age and younger normal individuals was evaluated on Pulmonary angiotensin II production and angiotensin I conversion. Angiotensin I conversion in the lung operates without impediment despite severe pulmonary injury, with arterial angiotensin II concentrations being 1.4-1.5 times that of mixed venous blood.
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