Key result
ARDS with sepsis is linked to ~58% lower serum ACE levels versus critically ill controls.
Why the study?
Are serum ACE levels decreased in patients with ARDS associated with sepsis compared to other critically ill patients?
Population
55 critically ill patients, including 24 controls, 11 with cardiogenic pulmonary edema, 8…
Comparison
Presence of ARDS with sepsis vs Critically ill controls, cardiogenic pulmonary…
Design
Cross-sectional
Authors
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Lower ACE levels were associated with sepsis in ARDS; hypothesis-generating for early biomarker use but requires prospective validation.
Observational (n=55)
Are serum ACE levels decreased in patients with ARDS associated with sepsis compared to other critically ill patients?
Absolute Event Rate: 8.6% vs 20.7%
Decreased serum ACE levels may serve as an early biomarker to identify sepsis as the etiology of ARDS prior to blood culture results.
Casey et al. (1981) conducted an observational in Adult respiratory distress syndrome (ARDS) and sepsis (n=55). Sepsis in ARDS vs. Critically ill controls and ARDS without sepsis was evaluated on Serum angiotensin converting enzyme (ACE) levels. Patients with ARDS and sepsis had markedly decreased serum ACE levels (8.6 +/- 2.3) compared to critically ill controls (20.7 +/- 2.8) and patients with ARDS without sepsis (19.0 +/- 5.5).
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