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January 14, 2010Critical Care Medicine

Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets

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Why the study?

Does recombinant angiotensin-converting enzyme 2 improve pulmonary hemodynamics and oxygenation in a piglet model of acute respiratory distress syndrome?

Population

15 anesthetized and mechanically ventilated piglets, including 12 with acute respiratory distress syndrome…

Comparison

Recombinant angiotensin-converting enzyme 2 vs Saline

Design

Preclinical, randomized, double-blinded

Authors

BTBenedikt TremlInnsbruck Medical UniversityNNNikolaus NeuStatistisches BundesamtAKAxel KleinsasserInnsbruck Medical University

Discussion

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Implication

Hypothesis-generating for recombinant ACE2 in ARDS; human trials needed before clinical consideration.

Structured PICO

Does recombinant angiotensin-converting enzyme 2 improve pulmonary hemodynamics and oxygenation in a piglet model of acute respiratory distress syndrome?

P
Population
15 anesthetized and mechanically ventilated piglets, including 12 with acute respiratory distress syndrome induced by lipopolysaccharide infusion and 3 without lipopolysaccharide pretreatment.
I
Intervention
Recombinant angiotensin-converting enzyme 2
C
Comparator
Saline
O
Outcome
Systemic and pulmonary hemodynamics, blood gas exchange parameters (PaO2), tumor necrosis factor-alpha, and angiotensin II levelssurrogate

Recombinant ACE2 attenuates arterial hypoxemia and pulmonary hypertension in a piglet model of ARDS, suggesting potential therapeutic utility.

Cite This Study

Treml et al. (2010) studied this question.

synapsesocial.com/papers/6a7580f1f1e99ff85ab1f2bfhttps://doi.org/10.1097/ccm.0b013e3181c03009
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