August 15, 2013Critical Care Medicine

Angiotensin-(1–7) Protects From Experimental Acute Lung Injury

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Why the study?

Does angiotensin-(1-7) protect against experimental acute lung injury in animal models?

Population

Male Sprague-Dawley rats, Balb/c mice, and C57Bl6/J mice with experimental acute lung injury; human…

Design

Preclinical

Authors

NKNadine KleinUniversity of Mannheim FGFlorian GembardtGeneral / Preventive / Lipids SSStephanie SupéCharité - Universitätsmedizin Berlin

Discussion

Member takes

Implication

Hypothesis-generating for angiotensin-(1-7) in acute lung injury; human trials required before clinical consideration.

Structured PICO

Does angiotensin-(1-7) protect against experimental acute lung injury in animal models?

Population

Male Sprague-Dawley rats, Balb/c mice, and C57Bl6/J mice with experimental acute lung injury (ventilator- or acid aspiration-induced in mice, oleic acid-induced in rats); human pulmonary microvascular endothelial cells in vitro

Intervention

Intravenous infusion of angiotensin-(1-7) or its nonpeptidic analog AVE0991

Outcome

Protection from acute lung injury (measured by lung edema, myeloperoxidase activity, histological lung injury score, pulmonary vascular resistance, and systemic arterial pressure)surrogate

Angiotensin-(1-7) and its analogs attenuate key features of acute lung injury in experimental models, suggesting a potential therapeutic strategy.

Cite This Study

Klein et al. (2013) studied this question.

synapsesocial.com/papers/6a73d6bfc1c8cbdb1d8de7d3 https://doi.org/10.1097/ccm.0b013e31828a6688

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Ask AI

Bookmark

Angiotensin-(1–7) Protects From Experimental Acute Lung Injury

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin-(1–7) Protects From Experimental Acute Lung Injury

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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