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March 1, 2012Wilderness and Environmental MedicineOpen Access

Recombinant Angiotensin-Converting Enzyme 2 Suppresses Pulmonary Vasoconstriction in Acute Hypoxia

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Why the study?

Does recombinant ACE2 reduce pulmonary arterial pressure and vascular resistance in a porcine model of acute hypoxia?

Population

12 anesthetized pigs instrumented with arterial, central venous, and Swan-Ganz catheters exposed to…

Comparison

Recombinant Angiotensin-Converting Enzyme 2 400… vs Control (placebo)

Design

Preclinical

Follow-up

180 minutes

Authors

AKAxel KleinsasserInnsbruck Medical UniversityIPIris PircherAmerican Institute of Certified Public AccountantsBTBenedikt TremlInnsbruck Medical University

Discussion

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Implication

Recombinant ACE2 merits testing in human hypoxia-related PH; extends animal data but leaves open clinical efficacy.

Structured PICO

Does recombinant ACE2 reduce pulmonary arterial pressure and vascular resistance in a porcine model of acute hypoxia?

P
Population
12 anesthetized pigs instrumented with arterial, central venous, and Swan-Ganz catheters exposed to normobaric hypoxia (fraction of inspired oxygen = 0.125) for 180 minutes.
I
Intervention
Recombinant Angiotensin-Converting Enzyme 2 (ACE2) 400 μg·kg(-1)
C
Comparator
Control (placebo)
O
Outcome
Pulmonary arterial pressure and pulmonary vascular resistancesurrogate

Recombinant ACE2 blunts the rise in pulmonary arterial pressure and vascular resistance during acute hypoxia in a porcine model, suggesting potential utility in hypoxia-associated pulmonary hypertension.

Cite This Study

Kleinsasser et al. (2012) studied this question.

synapsesocial.com/papers/6a7580f1f1e99ff85ab1f2bdhttps://doi.org/10.1016/j.wem.2011.09.002
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Also Consider

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  1. 1Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets2010 · 112 citations
  2. 2Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung1996 · 50 citations
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  4. 4A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-92000 · 3,176 citations
  5. 5Hypoxia- and non-hypoxia-related pulmonary hypertension — Established and new therapies2006 · 55 citations