Key result
Intravenous artesunate and oral artemether/lumefantrine resolve rare Plasmodium falciparum myocarditis in a 50-year-old man.
Why the study?
Cardiac complications are very rarely witnessed with severe malaria, with myocarditis reported in only a handful of cases in the literature.
Case Report (n=1)
No
Myocarditis is a rare but potentially reversible complication of severe Plasmodium falciparum malaria that requires prompt recognition and management.
Answers are grounded in this paper and cite their sources.
Raises awareness for reversible myocarditis in severe malaria; case-level data leave incidence and management open for prospective study.
Malaria remains one of the most prevalent infectious diseases globally. Despite targets set out by the WHO in 2015, there has been a rise in the number of cases since 2019 as an indirect effect of the COVID-19 pandemic. Cardiac complications are very rarely witnessed with severe malaria. Of the cardiac sequelae, myocarditis is one of the most frequently observed with a handful of case reports in the literature. We report a case of a man in his 50s who developed myocarditis while being managed for severe Plasmodium falciparum malaria in an intensive care unit in the UK and review the literature relevant to this case. This is the second reported case of this condition in the UK.
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Langdon et al. (2022) conducted a case report in Severe Plasmodium falciparum malaria complicated by myocarditis (n=1). Intravenous artesunate and oral artemether/lumefantrine (Riamet) was evaluated on Clinical recovery and improvement in cardiac function. A man in his 50s developed rare myocarditis secondary to severe Plasmodium falciparum malaria and successfully recovered following treatment with intravenous artesunate and oral artemether/lumefantrine.
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