Key result
Hyperlipidemia did not influence the expression of CD42b on resting and thrombin-activated platelets or fibrinogen concentration in patients after ischemic stroke.
Why the study?
Does hyperlipidemia influence platelet reactivity markers (CD42b expression and fibrinogen) in patients after ischemic stroke?
Observational (n=41)
Does hyperlipidemia influence platelet reactivity markers (CD42b expression and fibrinogen) in patients after ischemic stroke?
Patients in the convalescent phase of ischemic stroke exhibit increased platelet reactivity, but this is not significantly influenced by the presence of hyperlipidemia.
Does not support incorporating hyperlipidemia into post-stroke platelet reactivity assessment; leaves open other drivers of convalescent-phase changes.
The aim of this study was to assess platelet reactivity in patients after ischemic stroke and to investigate the influence of hyperlipidemia (HL) on platelet activity markers. A total of 41 patients after ischemic stroke were divided into the following 2 groups: patients with HL and patients with normolipidemia. Expression of CD42b on resting, thrombin-activated blood platelets, and fibrinogen level was assessed. The CD42b-positive platelets were analyzed using the flow cytometer, anti-CD61, and anti-CD42b monoclonal antibodies. The results confirmed increased platelet reactivity to thrombin in all patients after ischemic stroke manifested by significantly lower CD42b expression and percentage of CD42b(+) platelets after activation by thrombin. The influence of HL on the expression of CD42b on resting and thrombin-activated platelets was not found. However, increased level of fibrinogen but no influence of HL on fibrinogen concentration was observed in patients after ischemic stroke. Increased susceptibility to platelet agonists was found in patients after ischemic stroke in the convalescent phase.
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Pawelczyk et al. (2014) conducted an observational in Ischemic stroke (n=41). Hyperlipidemia vs. Normolipidemia was evaluated on Expression of CD42b on resting and thrombin-activated blood platelets, and fibrinogen level. Hyperlipidemia did not influence the expression of CD42b on resting and thrombin-activated platelets or fibrinogen concentration in patients after ischemic stroke.
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