Key result
L-citrulline improves vascular function and physical capacity in patients with HFpEF.
Why the study?
Does l-citrulline administration improve vascular function and physical capacity in patients with heart failure with preserved ejection fraction?
Does l-citrulline administration improve vascular function and physical capacity in patients with heart failure with preserved ejection fraction?
l-citrulline administration may improve vascular function and physical capacity in patients with HFpEF, suggesting a potential therapeutic role for targeting the l-Arg-NO pathway.
May support L-citrulline for vascular function in HFpEF; hypothesis-generating and requires randomized confirmation.
The current investigation has demonstrated that l-Cit administration may improve brachial artery endothelium-dependent vasodilation, upper and lower limb microvascular function, and physical capacity in patients with HFpEF, highlighting the potential therapeutic potential of interventions targeting the l-Arg-NO signaling cascade to improve outcomes in this patient group.
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Ratchford et al. (2022) studied this question. L-citrulline administration improved brachial artery endothelium-dependent vasodilation, upper and lower limb microvascular function, and physical capacity in patients with HFpEF.
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