What question did this study set out to answer?

This study aims to quantify the role of nitric oxide in flow-mediated dilation and assess the impact of different protocols and analysis methods.

November 26, 2013HypertensionOpen Access

Is Flow-Mediated Dilation Nitric Oxide Mediated?

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Why the study?

Does NO synthase blockade reduce flow-mediated dilation compared to saline infusion in humans?

Population

374 individual comparisons from 20 crossover studies measuring flow-mediated dilation (FMD) in humans

Comparison

Local infusion of NO synthase blocker… vs Local infusion of saline

Design

Meta-analysis

Authors

DGDaniel J. GreenBrigham Young University EDEllen A. DawsonVascular Medicine HGHans GroenewoudRadboud University Nijmegen

Discussion

Member takes

Implication

NO synthase blockade attenuates FMD; confirms partial nitric oxide mediation of conduit artery dilation in humans.

Key Points

This study aims to quantify the role of nitric oxide in flow-mediated dilation and assess the impact of different protocols and analysis methods.
Systematic review and 3-stage meta-analysis of 20 studies measuring flow-mediated dilation with NO synthase blocker and saline infusion.
Comparison of results from saline-infused tests against those with N(G)monomethyl-L-arginine (L-NMMA).
Analysis focused on results from different protocols including distal cuff placement and methods of continuous edge detection.
FMD(saline) was 8.2% (95% CI, 6.8%-9.6%) vs. FMD(L-NMMA) at 3.7% (95% CI, 3.1%-4.3%; P<0.001).
In healthy volunteers, FMD(saline) was 6.5% (95% CI, 5.7%-7.3%) compared to FMD(L-NMMA) at 0.9% (95% CI, 0.5%-1.3%; P<0.001).
Automated analysis showed FMD(saline) at 6.9% (95% CI, 6.0%-7.8%) and FMD(L-NMMA) at 2.4% (95% CI, 1.1%-3.7%; P<0.001).

Structured PICO

Does NO synthase blockade reduce flow-mediated dilation compared to saline infusion in humans?

Population

374 individual comparisons from 20 crossover studies measuring flow-mediated dilation (FMD) in humans

Intervention

Local infusion of NO synthase blocker N(G)monomethyl-L-arginine (L-NMMA)

Comparator

Local infusion of saline

Outcome

Difference in flow-mediated dilation (FMD) between infusion of saline and NO synthase blockersurrogate

This meta-analysis demonstrates that flow-mediated dilation of conduit arteries in humans is at least partially mediated by nitric oxide.

Cite This Study

Green et al. (2013) studied this question.

synapsesocial.com/papers/6a204f4b4ad5e85db1e71ea7 https://doi.org/10.1161/hypertensionaha.113.02044

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Is Flow-Mediated Dilation Nitric Oxide Mediated?

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Is Flow-Mediated Dilation Nitric Oxide Mediated?

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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