What does this research mean for the field?

Q: What does this research mean for the field?

Constitutive overexpression of insulin-like growth factor-1 (IGF-1) prevents myocyte apoptosis and necrosis after myocardial infarction, thereby limiting ventricular dilation, wall stress, and cardiac hypertrophy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 15, 1997Journal of Clinical InvestigationOpen Access

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.

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Why the study?

Does overexpression of IGF-1 prevent myocyte death and attenuate ventricular remodeling after myocardial infarction in mice?

Population

Transgenic mice overexpressing human IGF-1B in myocytes and wild-type nontransgenic littermates at 1.5 and…

Comparison

Constitutive overexpression of human IGF-1B in… vs Wild-type nontransgenic littermates subjected to…

Design

Preclinical, Tissue samples were coded, and the code was broken at the end of…

Follow-up

7 days

Authors

QLQ LiAnimal Science Research Institute BLB LiGeneral Hospital of Shenyang Military Region XWXiaohui WangJingdezhen University

Discussion

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Implication

Reduces post-MI remodeling in mice; leaves open whether IGF-1 modulation affects human ventricular dilation.

Structured PICO

Does overexpression of IGF-1 prevent myocyte death and attenuate ventricular remodeling after myocardial infarction in mice?

Population

Transgenic mice overexpressing human IGF-1B in myocytes (FVB.Igf+/-) and wild-type nontransgenic littermates at 1.5 and 2.5 months of age subjected to coronary ligation.

Intervention

Constitutive overexpression of human IGF-1B in myocytes.

Comparator

Wild-type nontransgenic littermates subjected to coronary ligation, and sham-operated controls.

Outcome

Myocyte apoptosis and necrosis, ventricular dilation, wall stress, and cardiac hypertrophy 7 days after infarction.surrogate

Constitutive overexpression of IGF-1 in mice protects against myocyte apoptosis and necrosis after myocardial infarction, thereby limiting ventricular dilation and hypertrophy.

Cite This Study

Li et al. (1997) studied this question.

synapsesocial.com/papers/6a17870d8d470cd9925360fa https://doi.org/10.1172/jci119730

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Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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