Why the study?
Does IGF-1 deficiency alter cardiac remodeling and function after experimental myocardial infarction in mice?
Population
Heterozygous IGF-1 deficient mice and wildtype mice subjected to experimental myocardial infarction via…
Comparison
Heterozygous IGF-1 deficiency vs Wildtype mice
Design
Preclinical
Follow-up
1 week
Authors
Loading...
Altered remodeling without functional change in IGF-1-deficient mice post-MI; leaves open IGF-1's role in repair, requiring translational studies.
Does IGF-1 deficiency alter cardiac remodeling and function after experimental myocardial infarction in mice?
IGF-1 deficiency in mice alters the cardiac remodeling process (reduced capillarization, blunted hypertrophy, increased apoptosis) but preserves cardiac function 1 week after myocardial infarction.
Meindert Palmen (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: