Key result
Elevated liver fat in newly diagnosed T2DM is linked to increased carotid pulse wave velocity.
Why the study?
Carotid atherosclerotic indicators and their associations with NAFLD had not been compared among patients with newly diagnosed type 2 diabetes mellitus, pre-diabetes mellitus, and healthy controls.
Is liver fat content associated with carotid endothelial function in patients with newly diagnosed type 2 diabetes mellitus and pre-diabetes mellitus?
Cross-Sectional (n=240)
Is liver fat content associated with carotid endothelial function in patients with newly diagnosed type 2 diabetes mellitus and pre-diabetes mellitus?
Absolute Event Rate: 14.57% vs 5.73%
p-value: p=.000
Elevated liver fat content and NAFLD prevalence in newly diagnosed T2DM are strongly associated with carotid atherosclerosis, suggesting a link between NAFLD and cardiovascular disease in T2DM.
Association of liver fat with carotid stiffness in new T2DM supports NAFLD-CVD link; leaves open causality and need for prospective trials.
This study aimed to compare carotid atherosclerotic indicators among patients with newly diagnosed type 2 diabetes mellitus (NT2DM), pre-diabetes mellitus (PDM), and healthy controls (HCs), and to investigate associations between nonalcoholic fatty liver disease (NAFLD) and carotid atherosclerosis. A total of 240 participants were enrolled (120 NT2DM, 60 PDM, and 60 HCs). Liver fat content (LFC) was assessed using proton magnetic resonance spectroscopy ([ 1 H]-MRS). Carotid intima-media thickness (CIMT) and carotid pulse wave velocity (PWV) at the beginning (BS-PWV) and end of systole (ES-PWV) were measured by ultrasonography. The levels of LFC were significantly higher in NT2DM (14.57% ± 6.49%) and PDM (11.44% ± 5.62%) than in HCs (5.73% ± 4.08%; P =.000). The prevalence of NAFLD was 66.7% in NT2DM, 38.3% in PDM, and 25.0% in HCs. CIMT, BS-PWV, and ES-PWV were significantly elevated in NT2DM compared with PDM and HCs (all P < .05). Multiple linear regression (MLR) analyses showed LFC and triglycerides were strong contributors to both BS-PWV and ES-PWV. Elevated LFC and NAFLD prevalence in NT2DM, together with their associations with carotid atherosclerosis, suggest a potential link between NAFLD and cardiovascular disease in T2DM.
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Zhu et al. (2025) conducted a cross-sectional in Newly diagnosed type 2 diabetes mellitus and pre-diabetes mellitus (n=240). Liver fat content (LFC) and NAFLD vs. Healthy controls was evaluated on Liver fat content (LFC) (p=.000). Elevated liver fat content in newly diagnosed T2DM (14.57%) compared to healthy controls (5.73%; P=.000) was a strong contributor to increased carotid pulse wave velocity.
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