Key result
In patients with type 1 diabetes, nonalcoholic fatty liver disease was associated with significantly greater carotid intima-media thickness (0.81 mm vs. 0.69 mm, p < 0.001) independent of conventional cardiovascular risk factors.
Why the study?
Is nonalcoholic fatty liver disease associated with increased carotid intima-media thickness in patients with type 1 diabetes?
Population
722 patients with type 1 diabetes, mean age 46.2 years, 51.1% male. Excluded: known causes of chronic liver…
Comparison
Presence of nonalcoholic fatty liver disease… vs Absence of nonalcoholic fatty liver disease
Design
Cross-sectional, Abdominal ultrasonography was performed by experienced…
Authors
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May flag higher subclinical atherosclerosis in type 1 diabetes; hypothesis-generating and requires prospective validation before practice change.
Cross-Sectional (n=722)
No
Is nonalcoholic fatty liver disease associated with increased carotid intima-media thickness in patients with type 1 diabetes?
Absolute Event Rate: 0.81% vs 0.69%
p-value: p=<0.001
In patients with type 1 diabetes, the presence of NAFLD is independently associated with increased carotid intima-media thickness, suggesting a higher burden of subclinical atherosclerosis.
Zhang et al. (2016) conducted a cross-sectional in Type 1 Diabetes (n=722). Nonalcoholic fatty liver disease (NAFLD) vs. Without fatty liver was evaluated on Carotid intima-media thickness (C-IMT) (p=<0.001). In patients with type 1 diabetes, nonalcoholic fatty liver disease was associated with significantly greater carotid intima-media thickness (0.81 mm vs. 0.69 mm, p < 0.001) independent of conventional cardiovascular risk factors.
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