Key result
Nonalcoholic fatty liver disease was significantly associated with a higher prevalence of carotid stenosis (OR 2.06) compared to individuals without the disease in a Chinese community population.
Why the study?
Is nonalcoholic fatty liver disease associated with carotid stenosis or plaque in a community-based Chinese population?
Cross-Sectional (n=2,612)
No
Is nonalcoholic fatty liver disease associated with carotid stenosis or plaque in a community-based Chinese population?
NAFLD is independently associated with a twofold increased odds of carotid stenosis in a Chinese community-based population aged 40 and older.
Answers are grounded in this paper and cite their sources.
Should not yet inform carotid screening or risk stratification; extends observational links in Chinese adults but leaves causality and outcomes open.
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases with a high prevalence in the general population. The association between NAFLD and cardiovascular disease has been well addressed in previous studies. However, whether NAFLD is associated with carotid artery disease in a community-based Chinese population remained unclear. The aim of this study was to investigate the association between NAFLD and carotid artery disease. METHODS: A total of 2612 participants (1091 men and 1521 women) aged 40 years and older from Jidong of Tangshan city (China) were selected for this study. NAFLD was diagnosed by abdominal ultrasonography. The presence of carotid stenosis or plaque was evaluated by carotid artery ultrasonography. Logistic regression was used to analyze the association between NAFLD and carotid artery disease. RESULTS: Participants with NAFLD have a higher prevalence of carotid stenosis (12.9% vs. 4.6%) and carotid plaque (21.9% vs. 15.0%) than those without NAFLD. After adjusting for age, gender, smoking status, income, physical activity, diabetes, hypertension, triglyceride, waist-hip ratio, and high-density lipoprotein, NAFLD is significantly associated with carotid stenosis (odds ratio [OR]: 2.06, 95% confidence interval [CI]: 1.45-2.91), but the association between NAFLD and carotid plaque is not statistically significant (OR: 1.10, 95% CI: 0.8-1.40). CONCLUSION: A significant association between NAFLD and carotid stenosis is found in a Chinese population.
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Guo et al. (2018) conducted a cross-sectional in Nonalcoholic fatty liver disease and carotid artery disease (n=2,612). Nonalcoholic fatty liver disease (NAFLD) vs. Without NAFLD was evaluated on Carotid stenosis (OR 2.06, 95% CI 1.45-2.91, p=<0.01). Nonalcoholic fatty liver disease was significantly associated with a higher prevalence of carotid stenosis (OR 2.06) compared to individuals without the disease in a Chinese community population.
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