What question did this study set out to answer?

To evaluate the efficacy of high-dose furosemide in patients with refractory congestive heart failure.

February 1, 1988Archives of Internal Medicine

High-Dose Furosemide in the Treatment of Refractory Congestive Heart Failure

View Full Paper

Ask AI

Bookmark

Why the study?

Does high-dose furosemide improve symptoms and survival in patients with severe refractory congestive heart failure and reduced renal function?

Population

n=35 patients with severe chronic congestive heart failure refractory to conventional therapy, with…

Design

Case_series

Follow-up

up to 36 months (mean survival 11.3 months)

Authors

PGP. G. G. GerlagSt. Joseph Hospital

Discussion

Member takes

Implication

High-dose furosemide may relieve symptoms in refractory HF with renal impairment; hypothesis-generating and should not yet change practice.

Key Points

To evaluate the efficacy of high-dose furosemide in patients with refractory congestive heart failure.
Administered high doses of furosemide (250 to 4000 mg/d) to 35 patients.
Monitored renal function and outcomes, including natriuresis and weight reduction.
Implemented long-term intermittent hemofiltration in cases where furosemide therapy failed.
All patients achieved natriuresis and a mean weight reduction of 11 kg.
Mean survival after starting high-dose furosemide therapy was 11.3 months (range, 0.5 to 36 months).
Eight patients receiving hemofiltration experienced an additional mean survival prolongation of 3.0 months.

Structured PICO

Does high-dose furosemide improve symptoms and survival in patients with severe refractory congestive heart failure and reduced renal function?

Population

n=35 patients with severe chronic congestive heart failure refractory to conventional therapy, with significantly reduced renal function.

Intervention

High-dose furosemide (250 to 4000 mg/d), with long-term intermittent hemofiltration performed in 8 selected cases when diuretic therapy eventually failed.

Outcome

Survival, weight reduction, and relief of symptomshard clinical

High-dose furosemide is effective for achieving natriuresis, weight reduction, and symptomatic relief in patients with severe, refractory congestive heart failure and renal impairment.

Cite This Study

P. G. G. Gerlag (1988) studied this question.

synapsesocial.com/papers/6a1789907afe20c06351e09c https://doi.org/10.1001/archinte.1988.00380020030006

Topics

Heart failure HFrEF treatment Heart failure hospitalization

View Full Paper

Ask AI

Bookmark

Implication

High-dose furosemide may relieve symptoms in refractory HF with renal impairment; hypothesis-generating and should not yet change practice.

High-Dose Furosemide in the Treatment of Refractory Congestive Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

High-Dose Furosemide in the Treatment of Refractory Congestive Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider