Key result
Two HeartMate 3 ventricular assist devices were used off-label as a total artificial heart replacement in 1 patient requiring a mechanical bridge to transplantation.
Why the study?
The need for biventricular support poses significant challenges for patients requiring a mechanical bridge to transplantation, and recent VAD improvements enable using two centrifugal flow VADs as a total artificial heart replacement.
Can two HeartMate 3 ventricular assist devices be used as a total artificial heart for biventricular support as a bridge to transplant?
Case Report (n=1)
Can two HeartMate 3 ventricular assist devices be used as a total artificial heart for biventricular support as a bridge to transplant?
Two HeartMate 3 ventricular assist devices can be used off-label as a total artificial heart to provide biventricular support as a bridge to transplantation.
May support dual HeartMate 3 use for biventricular failure as bridge to transplant; leaves open safety, durability, and generalizability.
The need for biventricular support poses significant challenges for patients who require a mechanical bridge to transplantation. Recent improvements in ventricular assist device (VAD) technology has made possible the use of two centrifugal flow VADs as a total artificial heart (TAH) replacement. The HeartMate 3 (HM3; [Full MagLev, Abbott Laboratories, Chicago, Illinois]) was recently approved as a destination therapy; this VAD has a number of unique advantages that allow for its off-label use for biventricular support. Here, we describe the use of two HM3s as a TAH in a patient as a bridge to transplant.
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Daneshmand et al. (2019) conducted a case report in Biventricular heart failure requiring bridge to transplantation (n=1). Two HeartMate 3 (HM3) ventricular assist devices as a total artificial heart was evaluated. Two HeartMate 3 ventricular assist devices were used off-label as a total artificial heart replacement in 1 patient requiring a mechanical bridge to transplantation.
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