Key result
Organic cation transporter 3 (OCT3) and other transporters mediate norepinephrine uptake into perivascular adipose tissue, as demonstrated by reduced uptake with specific inhibitors.
Organic cation transporter 3 (OCT3) mediates norepinephrine uptake into perivascular adipose tissue, providing a mechanism by which PVAT reduces vascular contraction.
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OCT3-mediated NE uptake in PVAT may influence vascular tone; leaves open human therapeutic relevance.
Ayala‐Lopez et al. (2015) studied Norepinephrine uptake in perivascular adipose tissue. Transporter inhibitors (nisoxetine, citalopram, corticosterone, desipramine) vs. Vehicle was evaluated on Norepinephrine and ASP(+) uptake in PVAT. Organic cation transporter 3 (OCT3) and other transporters mediate norepinephrine uptake into perivascular adipose tissue, as demonstrated by reduced uptake with specific inhibitors.
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