Key result
New protocol outlines planned meta-analysis evaluating isometric exercise for blood pressure in hypertension.
Why the study?
The hypotensive effect of isometric exercise in prehypertensive and hypertensive individuals is not fully understood.
Does isometric handgrip exercise reduce blood pressure in adults with prehypertension or hypertension?
Systematic Review
Does isometric handgrip exercise reduce blood pressure in adults with prehypertension or hypertension?
This paper outlines a protocol for a systematic review and meta-analysis to determine the blood pressure-lowering effects of isometric handgrip exercise in prehypertensive and hypertensive individuals.
Protocol for meta-analysis of isometric exercise on BP; leaves open current recommendations pending synthesis of trials.
BACKGROUND: Systemic arterial hypertension (HTN) is the leading risk factor of cardiovascular disease death. Lifestyle changes are key for the prevention and management of HTN. Regular aerobic exercise training is recommended as part of the management of HTN, and dynamic resistance exercise should be prescribed as an adjuvant to aerobic training. Recent evidence points to the potential benefits of isometric resistance training in reducing blood pressure (BP). Yet, the hypotensive effect of isometric exercise in prehypertensive and hypertensive individuals is not fully understood. Thus, we will examine the effect of isometric exercise in prehypertensive and hypertensive individuals through a systematic review and meta-analysis. METHODS: Our systematic review study will include randomized controlled trials (RCTs) selected from the electronic databases MEDLINE (PubMed), Cochrane, LILACS, EMBASE, Web of Science, and PEDro published in English, Spanish, and Portuguese languages. We will follow the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) and PICOS framework. Our search will involve studies with both male and female participants aged 18 years or more diagnosed with prehypertension or HTN performing one session of isometric exercise (acute effect) or isometric exercise training (chronic effect) compared to a control group (no exercise). We will use the Cochrane Risk of Bias 2 (RoB 2) tool to evaluate the quality of the studies and RStudio software (v1.3.959 for Windows) for statistical analyses. DISCUSSION: A meta-analysis of a homogeneous sample of prehypertensive and hypertensive individuals involving isometric handgrip exercise alone can further support previous findings and improve our understanding and recommendations for the management of these populations. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42020213081.
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Oliveira et al. (2022) conducted a systematic review in Prehypertension and Hypertension. Isometric resistance exercise or training vs. No exercise or training was evaluated on Systolic and diastolic blood pressure. This paper is a study protocol for a systematic review and meta-analysis to evaluate the effect of isometric exercise on blood pressure in prehypertensive and hypertensive individuals.
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