Methodological evaluation demonstrates robust vaccine effectiveness estimation in surveillance populations, highlighting models that correct confounding and over-dispersion.
The screening method provides a simple and rapid way of estimating vaccine effectiveness. The paper discusses the validity of the screening method with particular reference to bias and precision. Methods for correcting confounding, adjusting for covariates and over-dispersion, and deriving confidence limits are discussed in a modelling framework. The methods are illustrated using data on measles and pertussis vaccines.
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Paddy Farrington (1993) studied this question.
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