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September 18, 2017Nöro Psikiyatri Arşivi

Evaluation of Heart Rate Variability in Drug Free Panic Disorder Patients

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Key result

Drug-free panic disorder patients showed no significant differences in 24-hour heart rate variability parameters compared to healthy controls.

Why the study?

Does panic disorder alter 24-hour heart rate variability parameters compared to healthy controls?

Population

32 drug-free patients with panic disorder based on DSM-IV criteria, mean age 33.12, 20 female. Key…

Comparison

Panic disorder (observational exposure) vs 24 age and gender-matched healthy individuals…

Design

Case-control

Follow-up

24 hours

Authors

GDGozde Sirin DurduIzmir UniversityMKMeral KayıkçıoğluGeneral / Preventive / LipidsŞPŞebnem PırıldarEge University

Discussion

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Implication

No immediate clinical implications for HRV assessment in drug-free panic disorder; hypothesis-generating for state-dependent or comorbid autonomic changes.

Study Design

Type

Case-Control (n=56)

Multicenter

No

Structured PICO

Does panic disorder alter 24-hour heart rate variability parameters compared to healthy controls?

P
Population
32 drug-free patients with panic disorder (PD) based on DSM-IV criteria, mean age 33.12, 20 female. Key inclusion: psychotrope free for at least 2 weeks (3 weeks for fluoxetine), panic attack at least once in last month.
I
Intervention
Panic disorder (observational exposure)
C
Comparator
24 age and gender-matched healthy individuals without any cardiac, endocrine (including diabetes), and neurological disease
O
Outcome
24-hour heart rate variability (HRV) parameters including time domain (RMSSD, PNN50, SDNN, SDANN) and frequency domain (LF, HF, LF/HF, VLF, Total Power) measuressurrogate

Main Result

Absolute Event Rate: 33% vs 36%

p-value: p=0.229

In drug-free patients with panic disorder, 24-hour heart rate variability parameters did not significantly differ from healthy controls, suggesting autonomic function as measured by HRV may not be persistently impaired when assessed over a full day.

Limitations

  • Presence of comorbidities in PD group
  • Exclusion of the smoking habit of the patients
  • Not evaluating weight and physical activity levels
  • Unavailability of polysomnographic recordings for sleep-wake analysis

Cite This Study

Durdu et al. (2017) conducted a case-control in Panic Disorder (n=56). Panic disorder vs. Healthy controls was evaluated on 24-hour heart rate variability (RMSSD in ms) (p=0.229). Drug-free panic disorder patients showed no significant differences in 24-hour heart rate variability parameters compared to healthy controls.

synapsesocial.com/papers/6a1794e34f2b3115b012bea6https://doi.org/10.5152/npa.2017.19429
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased R‐R variance in panic disorder patients1990 · 123 citations
  2. 2The Relationship Between Heart Rate Recovery and Heart Rate Variability in Coronary Artery Disease2006 · 90 citations
  3. 3Effects of Smoking Cessation on Blood Pressure and Heart Rate Variability in Habitual Smokers1999 · 253 citations
  4. 4Decreased cardiac vagal control in drug‐naive patients with panic disorder: A case‐control study in T aiwan2013 · 28 citations
  5. 5Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients2010 · 57 citations