Key result
In patients with panic disorder, the presence of moderate to severe depression was associated with a reduced low frequency/high frequency (LF/HF) ratio.
Why the study?
Panic disorder is highly associated with autonomic dysfunction and often accompanied by depression, but the association between depression and heart rate variability indices in these patients needed determination.
Observational (n=111)
No
In patients with panic disorder, a decreased LF/HF ratio on heart rate variability is associated with comorbid depression.
Answers are grounded in this paper and cite their sources.
Comorbid depression may worsen autonomic imbalance in panic disorder; hypothesis-generating for integrated management and prospective validation.
Objective: Heart rate variability (HRV) reflects the regulation of the autonomic nervous system. Panic disorder is highly associated with autonomic dysfunction, and is often accompanied by depression. The aim of this study is to determine the association between depression and HRV indices in patients with panic disorder. Methods: A total of 110 outpatients diagnosed with panic disorder participated in this study. The medical records of patients with panic disorder who visited the outpatient clinic of Konkuk University Hospital between December 2018 and March 2020 were retrospectively reviewed. Measurements used in this study include the Panic Disorder Severity Scale-Self Report, Beck Depression Inventory (BDI-II), Insomnia Severity Index, and HRV. Patients were divided into depressive and non-depressive groups based on their BDI-II scores. The association between HRV indices and depressive symptoms was statistically analyzed. Results: /Hz), LF, HF, and LF/HF. Conclusion: We confirmed that the LF/HF ratio decreases when depression is accompanied by panic disorder. HRV indices may be useful markers for detecting depressive symptoms in patients with panic disorder.
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Hong et al. (2022) conducted an observational in Panic Disorder (n=111). Comorbid depression vs. No depression was evaluated on Low frequency/high frequency (LF/HF) ratio (p=0.004). In patients with panic disorder, the presence of moderate to severe depression was associated with a reduced low frequency/high frequency (LF/HF) ratio.
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